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Antiviral and Anticancer Optimization Studies of the DNA-binding Marine Natural Product Aaptamine
Aaptamine has potent cytotoxicity that may be explained by its ability to intercalate DNA. Aaptamine was evaluated for its ability to bind to DNA to validate DNA binding as the primary mechanism of cytotoxicity. Based on UV–vis absorbance titration data, the K(obs) for aaptamine was 4.0 (±0.2) × 10(...
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| Publicado no: | Chem Biol Drug Des |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4918911/ https://ncbi.nlm.nih.gov/pubmed/18251774 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1747-0285.2008.00628.x |
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