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Metabolic and behavioral effects of mutant huntingtin deletion in Sim1 neurons in the BACHD mouse model of Huntington’s disease

Hypothalamic pathology, metabolic dysfunction and psychiatric symptoms are part of Huntington disease (HD), which is caused by an expanded CAG repeat in the huntingtin (HTT) gene. Inactivation of mutant HTT selectively in the hypothalamus prevents the development of metabolic dysfunction and depress...

詳細記述

保存先:
書誌詳細
出版年:Sci Rep
主要な著者: Soylu-Kucharz, Rana, Baldo, Barbara, Petersén, Åsa
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group 2016
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4917832/
https://ncbi.nlm.nih.gov/pubmed/27334347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep28322
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