A phase I pharmacokinetics trial comparing PF‐05280586 (a potential biosimilar) and rituximab in patients with active rheumatoid arthritis

AIMS: Pharmacokinetic (PK) similarity was assessed among PF‐05280586 (a proposed biosimilar) vs. rituximab sourced from the European Union (rituximab‐EU) and the United States (rituximab‐US). Pharmacodynamics (PD), overall safety and immunogenicity were also evaluated. METHODS: Patients with active...

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Bibliografiska uppgifter
I publikationen:Br J Clin Pharmacol
Huvudupphovsmän: Cohen, Stanley, Emery, Paul, Greenwald, Maria, Yin, Donghua, Becker, Jean‐Claude, Melia, Lisa Ann, Li, Ruifeng, Gumbiner, Barry, Thomas, Dolca, Spencer‐Green, George, Meng, Xu
Materialtyp: Artigo
Språk:Inglês
Publicerad: John Wiley and Sons Inc. 2016
Ämnen:
Pharmacokinetic Dynamic Relationships
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4917800/
https://ncbi.nlm.nih.gov/pubmed/26909489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12916
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