Mechanism of dioxin action: Ah receptor-mediated increase in promoter accessibility in vivo.
We have analyzed dioxin-inducible, Ah receptor-dependent changes in protein-DNA interactions at the CYP1A1 transcriptional promoter in intact mouse hepatoma cells. Our findings indicate that in uninduced cells, the promoter is inaccessible to its cognate binding proteins, which are known to be expre...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1992
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC49177/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1317573/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.11.4811 |
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