Distal retinal ganglion cell axon transport loss and activation of p38 MAPK stress pathway following VEGF-A antagonism

There is increasing evidence that VEGF-A antagonists may be detrimental to neuronal health following ocular administration. Here we investigated firstly the effects of VEGF-A neutralization on retinal neuronal survival in the Ins2(Akita) diabetic and JR5558 spontaneous choroidal neovascularization (...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Foxton, R, Osborne, A, Martin, K R, Ng, Y-S, Shima, D T
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4917649/
https://ncbi.nlm.nih.gov/pubmed/27148685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2016.110
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