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Mitochondrial Complex 1 Activity Measured by Spectrophotometry Is Reduced across All Brain Regions in Ageing and More Specifically in Neurodegeneration

Mitochondrial function, in particular complex 1 of the electron transport chain (ETC), has been shown to decrease during normal ageing and in neurodegenerative disease. However, there is some debate concerning which area of the brain has the greatest complex 1 activity. It is important to identify t...

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Bibliographic Details
Published in:PLoS One
Main Authors: Pollard, Amelia Kate, Craig, Emma Louise, Chakrabarti, Lisa
Format: Artigo
Language:Inglês
Published: Public Library of Science 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4917223/
https://ncbi.nlm.nih.gov/pubmed/27333203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0157405
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