Functional Studies on Primary Tubular Epithelial Cells Indicate a Tumor Suppressor Role of SETD2 in Clear Cell Renal Cell Carcinoma()

SET domain-containing 2 (SETD2) is responsible for the trimethylation of histone H3 lysine36 (H3K36me3) and is one of the genes most frequently mutated in clear cell renal cell carcinoma (ccRCC). It is located at 3p21, one copy of which is lost in the majority of ccRCC tumors, suggesting that SETD2...

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Dettagli Bibliografici
Pubblicato in:Neoplasia
Autori principali: Li, Jun, Kluiver, Joost, Osinga, Jan, Westers, Helga, van Werkhoven, Maaike B, Seelen, Marc A., Sijmons, Rolf H., van den Berg, Anke, Kok, Klaas
Natura: Artigo
Lingua:Inglês
Pubblicazione: Neoplasia Press 2016
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Original article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4916950/
https://ncbi.nlm.nih.gov/pubmed/27292023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neo.2016.04.005
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