An HSV-based library screen identifies PP1α as a negative TRPV1 regulator with analgesic activity in models of pain

Transient receptor potential vanilloid 1 (TRPV1) is a pronociceptive cation channel involved in persistent inflammatory and neuropathic pain. Herpes simplex virus (HSV) vector expression of TRPV1 causes cell death in the presence of capsaicin, thereby completely blocking virus replication. Here we d...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Mol Ther Methods Clin Dev
Hlavní autoři: Reinhart, Bonnie, Goins, William F, Harel, Asaff, Chaudhry, Suchita, Goss, James R, Yoshimura, Naoki, de Groat, William C, Cohen, Justus B, Glorioso, Joseph C
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4916946/
https://ncbi.nlm.nih.gov/pubmed/27382601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtm.2016.40
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky