Chemoimmunotherapy with O-FC in previously untreated patients with chronic lymphocytic leukemia

We conducted an international phase 2 trial to evaluate 2 dose levels of ofatumumab, a human CD20 mAb, combined with fludarabine and cyclophosphamide (O-FC) as frontline therapy for chronic lymphocytic leukemia (CLL). Patients with active CLL were randomized to ofatumumab 500 mg (n = 31) or 1000 mg...

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Vydáno v:Blood
Hlavní autoři: Wierda, William G., Kipps, Thomas J., Dürig, Jan, Griskevicius, Laimonas, Stilgenbauer, Stephan, Mayer, Jiří, Smolej, Lukáš, Hess, Georg, Griniute, Rasa, Hernandez-Ilizaliturri, Francisco J., Padmanabhan, Swaminathan, Gorczyca, Michele, Chang, Chai-Ni, Chan, Geoffrey, Gupta, Ira, Nielsen, Tina G., Russell, Charlotte A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2011
Témata:
Clinical Trials and Observations
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4916561/
https://ncbi.nlm.nih.gov/pubmed/21498674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-12-323980
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