The Bruton tyrosine kinase inhibitor PCI-32765 thwarts chronic lymphocytic leukemia cell survival and tissue homing in vitro and in vivo

B-cell receptor (BCR) signaling is a critical pathway in the pathogenesis of several B-cell malignancies, including chronic lymphocytic leukemia (CLL), and can be targeted by inhibitors of BCR-associated kinases, such as Bruton tyrosine kinase (Btk). PCI-32765, a selective, irreversible Btk inhibito...

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Bibliographic Details
Published in:Blood
Main Authors: Ponader, Sabine, Chen, Shih-Shih, Buggy, Joseph J., Balakrishnan, Kumudha, Gandhi, Varsha, Wierda, William G., Keating, Michael J., O'Brien, Susan, Chiorazzi, Nicholas, Burger, Jan A.
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2012
Subjects:
Lymphoid Neoplasia
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4916557/
https://ncbi.nlm.nih.gov/pubmed/22180443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-10-386417
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