Disruption of Coordinated Presynaptic and Postsynaptic Maturation Underlies the Defects in Hippocampal Synapse Stability and Plasticity in Abl2/Arg-Deficient Mice

Immature glutamatergic synapses in cultured neurons contain high-release probability (P(r)) presynaptic sites coupled to postsynaptic sites bearing GluN2B-containing NMDA receptors (NMDARs), which mature into low-P(r), GluN2B-deficient synapses. Whether this coordinated maturation of high-P(r), GluN...

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Vydáno v:J Neurosci
Hlavní autoři: Xiao, Xiao, Levy, Aaron D., Rosenberg, Brian J., Higley, Michael J., Koleske, Anthony J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2016
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4916252/
https://ncbi.nlm.nih.gov/pubmed/27335408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4092-15.2016
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