Lack of Skeletal Muscle IL-6 Affects Pyruvate Dehydrogenase Activity at Rest and during Prolonged Exercise

Pyruvate dehydrogenase (PDH) plays a key role in the regulation of skeletal muscle substrate utilization. IL-6 is produced in skeletal muscle during exercise in a duration dependent manner and has been reported to increase whole body fatty acid oxidation, muscle glucose uptake and decrease PDHa acti...

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Bibliographic Details
Published in:PLoS One
Main Authors: Gudiksen, Anders, Schwartz, Camilla Lindgren, Bertholdt, Lærke, Joensen, Ella, Knudsen, Jakob G., Pilegaard, Henriette
Format: Artigo
Language:Inglês
Published: Public Library of Science 2016
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4915712/
https://ncbi.nlm.nih.gov/pubmed/27327080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0156460
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