CYP2C19 and CES1 polymorphisms and efficacy of clopidogrel and aspirin dual antiplatelet therapy in patients with symptomatic intracranial atherosclerotic disease

OBJECTIVE: Symptomatic intracranial atherosclerotic disease (ICAD) has a high risk of recurrent stroke. Genetic polymorphisms in CYP2C19 and CES1 are associated with adverse outcomes in cardiovascular patients, but have not been studied in ICAD. The authors studied CYP2C19 and CES1 single-nucleotide...

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Publicado no:J Neurosurg
Main Authors: Hoh, Brian L., Gong, Yan, McDonough, Caitrin W., Waters, Michael F., Royster, Adrienne J., Sheehan, Tiffany O., Burkley, Ben, Langaee, Taimour Y., Mocco, J, Zuckerman, Scott L., Mummareddy, Nishit, Stephens, Marcus L., Ingram, Christie, Shaffer, Christian M., Denny, Joshua C., Brilliant, Murray H., Kitchner, Terrie E., Linneman, James G., Roden, Dan M., Johnson, Julie A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4915569/
https://ncbi.nlm.nih.gov/pubmed/26587656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3171/2015.6.JNS15795
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