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Differences in quantification of DNA double-strand breaks assessed by 53BP1/γH2AX focus formation assays and the comet assay in mammalian cells treated with irradiation and N-acetyl-L-cysteine

The biological effect of ionizing radiation (IR) on genomic DNA is thought to be either direct or indirect; the latter is mediated by IR induction of free radicals and reactive oxygen species (ROS). This study was designed to evaluate the effect of N-acetyl-L-cysteine (NAC), a well-known ROS-scaveng...

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Detaylı Bibliyografya
Yayımlandı:J Radiat Res
Asıl Yazarlar: Kurashige, Tomomi, Shimamura, Mika, Nagayama, Yuji
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2016
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4915540/
https://ncbi.nlm.nih.gov/pubmed/26951077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jrr/rrw001
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