Enhancement of Fear Extinction with Deep Brain Stimulation: Evidence for Medial Orbitofrontal Involvement

Deep brain stimulation (DBS) of the ventral capsule/ventral striatum (VC/VS) reduces anxiety, fear, and compulsive symptoms in patients suffering from refractory obsessive-compulsive disorder. In a rodent model, DBS-like high-frequency stimulation of VS can either enhance or impair extinction of con...

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Detalhes bibliográficos
Publicado no:Neuropsychopharmacology
Main Authors: Rodriguez-Romaguera, Jose, Do-Monte, Fabricio H, Tanimura, Yoko, Quirk, Gregory J, Haber, Suzanne N
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4915256/
https://ncbi.nlm.nih.gov/pubmed/25601229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2015.20
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