Protection against doxorubicin-induced myocardial dysfunction in mice by cardiac-specific expression of carboxyl terminus of hsp70-interacting protein

Carboxyl terminus of Hsp70-interacting protein (CHIP) is a critical ubiquitin ligase/cochaperone to reduce cardiac oxidative stress, inflammation, cardiomyocyte apoptosis and autophage etc. However, it is unclear whether overexpression of CHIP in the heart would exert protective effects against DOX-...

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Publicat a:Sci Rep
Autors principals: Wang, Lei, Zhang, Tian-Peng, Zhang, Yuan, Bi, Hai-Lian, Guan, Xu-Min, Wang, Hong-Xia, Wang, Xia, Du, Jie, Xia, Yun-Long, Li, Hui-Hua
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4914971/
https://ncbi.nlm.nih.gov/pubmed/27323684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep28399
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