Structural Insights into Recognition of Hydrolyzed Carbapenems and Inhibitors by Subclass B3 Metallo-β-Lactamase SMB-1

Metallo-β-lactamases (MBLs) confer resistance to carbapenems, and their increasing global prevalence is a growing clinical concern. To elucidate the mechanisms by which these enzymes recognize and hydrolyze carbapenems, we solved 1.4 to 1.6 Å crystal structures of SMB-1 (Serratia metallo-β-lactamase...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Wachino, Jun-ichi, Yamaguchi, Yoshihiro, Mori, Shigetarou, Jin, Wanchun, Kimura, Kouji, Kurosaki, Hiromasa, Arakawa, Yoshichika
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
Assuntos:
Mechanisms of Resistance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4914674/
https://ncbi.nlm.nih.gov/pubmed/27161644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.03108-15
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