Geographic Differences in the Contribution of ubiA Mutations to High-Level Ethambutol Resistance in Mycobacterium tuberculosis

Ethambutol (EMB) resistance can evolve through a multistep process, and mutations in the ubiA (Rv3806c) gene appear to be responsible for high-level EMB resistance in Mycobacterium tuberculosis. We evaluated the prevalence of ubiA and embB (Rv3795) mutations in EMB-resistant strains originating from...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Lingaraju, Subramanya, Rigouts, Leen, Gupta, Aditi, Lee, Jongseok, Umubyeyi, Alaine Nyaruhirira, Davidow, Amy L., German, Susan, Cho, EunJin, Lee, Ji-im, Cho, Sang-Nae, Kim, Cheon Tae, Alland, David, Safi, Hassan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
Assuntos:
Mechanisms of Resistance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4914663/
https://ncbi.nlm.nih.gov/pubmed/27139478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.03002-15
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