Aryl Hydrocarbon Receptor Deficiency in an Exon 3 Deletion Mouse Model Promotes Hematopoietic Stem Cell Proliferation and Impacts Endosteal Niche Cells

The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor belonging to the Per-Arnt-Sim (PAS) family of proteins. The AHR is involved in hematopoietic stem cell (HSC) functions including self-renewal, proliferation, quiescence, and differentiation. We hypothesize that AHR impact...

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Veröffentlicht in:Stem Cells Int
Hauptverfasser: Unnisa, Zeenath, Singh, Kameshwar P., Henry, Ellen C., Donegan, Catherine L., Bennett, John A., Gasiewicz, Thomas A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Hindawi Publishing Corporation 2016
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4913018/
https://ncbi.nlm.nih.gov/pubmed/27366154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2016/4536187
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