Sessile Serrated Polyps are Precursors of Colon Carcinomas Predominantly with Deficient DNA Mismatch Repair

OBJECTIVES: To establish sessile serrated adenoma/polyps (SSA/Ps) as direct precursors of CRC, we identified colon carcinomas (CC) arising from SSA/Ps and examined molecular features of the serrated neoplasia pathway. METHODS: Thirty-three CCs arising from SSA/Ps were identified among 2,646 CCs incl...

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Udgivet i:Clin Gastroenterol Hepatol
Main Authors: Sweetser, Seth, Jones, Andrea, Smyrk, Thomas C., Sinicrope, Frank A.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4912894/
https://ncbi.nlm.nih.gov/pubmed/26898652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cgh.2016.01.021
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