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An RNA matchmaker protein regulates the activity of the long noncoding RNA HOTAIR
The human long noncoding RNA (lncRNA) HOTAIR acts in trans to recruit the Polycomb repressive complex 2 (PRC2) to the HOXD gene cluster and to promote gene silencing during development. In breast cancers, overexpression of HOTAIR increases metastatic potential via the repression of many additional g...
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| Veröffentlicht in: | RNA |
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| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Cold Spring Harbor Laboratory Press
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4911922/ https://ncbi.nlm.nih.gov/pubmed/27146324 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.055830.115 |
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