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YAP mediates tumorigenesis in neurofibromatosis type 2 by promoting cell survival and proliferation through a COX-2-EGFR signaling axis
The Hippo-YAP pathway has emerged as a major driver of tumorigenesis in many human cancers. YAP is a transcriptional co-activator and while details of YAP regulation are quickly emerging, it remains unknown what downstream targets are critical for YAP’s oncogenic functions. To determine the mechanis...
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| Veröffentlicht in: | Cancer Res |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4911274/ https://ncbi.nlm.nih.gov/pubmed/27216189 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-1144 |
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