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Molecular Dynamics Simulations and Structural Analysis to Decipher Functional Impact of a Twenty Residue Insert in the Ternary Complex of Mus musculus TdT Isoform

Insertions/deletions are common evolutionary tools employed to alter the structural and functional repertoire of protein domains. An insert situated proximal to the active site or ligand binding site frequently impacts protein function; however, the effect of distal indels on protein activity and/or...

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Vydáno v:PLoS One
Hlavní autoři: Mutt, Eshita, Sowdhamini, Ramanathan
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2016
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4911049/
https://ncbi.nlm.nih.gov/pubmed/27311013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0157286
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