De Novo Assembly of Human Herpes Virus Type 1 (HHV-1) Genome, Mining of Non-Canonical Structures and Detection of Novel Drug-Resistance Mutations Using Short- and Long-Read Next Generation Sequencing Technologies

Human herpesvirus type 1 (HHV-1) has a large double-stranded DNA genome of approximately 152 kbp that is structurally complex and GC-rich. This makes the assembly of HHV-1 whole genomes from short-read sequencing data technically challenging. To improve the assembly of HHV-1 genomes we have employed...

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Vydáno v:PLoS One
Hlavní autoři: Karamitros, Timokratis, Harrison, Ian, Piorkowska, Renata, Katzourakis, Aris, Magiorkinis, Gkikas, Mbisa, Jean Lutamyo
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2016
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4910999/
https://ncbi.nlm.nih.gov/pubmed/27309375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0157600
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