Nanodrug formulations to enhance HIV drug exposure in lymphoid tissues and cells: clinical significance and potential impact on treatment and eradication of HIV/AIDS

Although oral combination antiretroviral therapy effectively clears plasma HIV, patients on oral drugs exhibit much lower drug concentrations in lymph nodes than blood. This drug insufficiency is linked to residual HIV in cells of lymph nodes. While nanoformulations improve drug solubility, safety a...

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Vydáno v:Nanomedicine (Lond)
Hlavní autoři: Shao, Jingwei, Kraft, John C, Li, Bowen, Yu, Jesse, Freeling, Jennifer, Koehn, Josefin, Ho, Rodney JY
Médium: Artigo
Jazyk:Inglês
Vydáno: Future Medicine Ltd 2016
Témata:
Review
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4910949/
https://ncbi.nlm.nih.gov/pubmed/26892323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2217/nnm.16.1
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