Targeting B-cell neoplasia with T-cell receptors recognizing a CD20-derived peptide on patient-specific HLA

T cells engineered to express chimeric antigen receptors (CARs) targeted to CD19 are effective in treatment of B-lymphoid malignancies. However, CARs recognize all CD19 positive (pos) cells, and durable responses are linked to profound depletion of normal B cells. Here, we designed a strategy to spe...

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Detalhes bibliográficos
Publicado no:Oncoimmunology
Main Authors: Mensali, Nadia, Ying, Fan, Sheng, Vincent Oei Yi, Yang, Weiwen, Walseng, Even, Kumari, Shraddha, Fallang, Lars-Egil, Kolstad, Arne, Uckert, Wolfgang, Malmberg, Karl Johan, Wälchli, Sébastien, Olweus, Johanna
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2016
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4910751/
https://ncbi.nlm.nih.gov/pubmed/27467957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2016.1138199
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