The multidrug-resistance transporter Abcc3 protects NK cells from chemotherapy in a murine model of malignant glioma

Abcc3, a member of the ATP-binding cassette transporter superfamily, plays a role in multidrug resistance. Here, we found that Abcc3 is highly expressed in blood-derived NK cells but not in CD8(+) T cells. In GL261 glioma-bearing mice treated with the alkylating agent temozolomide (TMZ) for 5 d, an...

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Vydáno v:Oncoimmunology
Hlavní autoři: Pessina, Sara, Cantini, Gabriele, Kapetis, Dimos, Cazzato, Emanuela, Di Ianni, Natalia, Finocchiaro, Gaetano, Pellegatta, Serena
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2015
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4910710/
https://ncbi.nlm.nih.gov/pubmed/27467914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2015.1108513
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