Pentamidine analogs as inhibitors of [(3)H]MK-801 and [(3)H]ifenprodil binding to rat brain NMDA receptors

The anti-protozoal drug pentamidine is active against opportunistic Pneumocystis pneumonia, but in addition has several other biological targets, including the NMDA receptor (NR). Here we describe the inhibitory potencies of 76 pentamidine analogs at 2 binding sites of the NR, the channel binding si...

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Pubblicato in:Bioorg Med Chem
Autori principali: Berger, Michael L., Maciejewska, Dorota, Vanden Eynde, Jean Jacques, Mottamal, Madhusoodanan, Żabiński, Jerzy, Kaźmierczak, Paweł, Rezler, Mateusz, Jarak, Ivana, Piantanida, Ivo, Karminski-Zamola, Grace, Mayence, Annie, Rebernik, Patrick, Kumar, Arvind, Ismail, Mohamed A., Boykin, David W., Huang, Tien L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4910395/
https://ncbi.nlm.nih.gov/pubmed/26117647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2015.06.012
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