Pentamidine analogs as inhibitors of [(3)H]MK-801 and [(3)H]ifenprodil binding to rat brain NMDA receptors

The anti-protozoal drug pentamidine is active against opportunistic Pneumocystis pneumonia, but in addition has several other biological targets, including the NMDA receptor (NR). Here we describe the inhibitory potencies of 76 pentamidine analogs at 2 binding sites of the NR, the channel binding si...

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Veröffentlicht in:Bioorg Med Chem
Hauptverfasser: Berger, Michael L., Maciejewska, Dorota, Vanden Eynde, Jean Jacques, Mottamal, Madhusoodanan, Żabiński, Jerzy, Kaźmierczak, Paweł, Rezler, Mateusz, Jarak, Ivana, Piantanida, Ivo, Karminski-Zamola, Grace, Mayence, Annie, Rebernik, Patrick, Kumar, Arvind, Ismail, Mohamed A., Boykin, David W., Huang, Tien L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4910395/
https://ncbi.nlm.nih.gov/pubmed/26117647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2015.06.012
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