Germ-line mutations of the APC gene in 53 familial adenomatous polyposis patients.

We searched for germ-line mutations of the APC gene in 79 unrelated patients with familial adenomatous polyposis using a ribonuclease protection analysis coupled with polymerase chain reaction amplifications of genomic DNA. Mutations were found in 53 patients (67%); 28 of the mutations were small de...

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Hauptverfasser: Miyoshi, Y, Ando, H, Nagase, H, Nishisho, I, Horii, A, Miki, Y, Mori, T, Utsunomiya, J, Baba, S, Petersen, G
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1992
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC49100/
https://ncbi.nlm.nih.gov/pubmed/1316610
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