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Stable isotope-assisted LC-MS/MS monitoring of glyceryl trinitrate bioactivation in a cell culture model of nitrate tolerance
The nitric oxide (NO) metabolites nitrite (NO(2)(−)) and nitrate (NO(3)(−)) can be quantified as an endpoint of endothelial function. We developed a LC-MS/MS method of measuring nitrite and nitrate isotopologues, which has a lower limit of quantification (LLOQ) of 1 nM. This method allows for isotop...
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| Udgivet i: | J Chromatogr B Analyt Technol Biomed Life Sci |
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| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4909631/ https://ncbi.nlm.nih.gov/pubmed/26796748 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jchromb.2015.12.010 |
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