Effects of local irradiation combined with sunitinib on early remodeling, mitochondria, and oxidative stress in the rat heart

BACKGROUND AND PURPOSE: Thoracic (chemo)radiation therapy is increasingly administered with tyrosine kinase inhibitors (TKI). While TKI have adverse effects on the heart, it is unknown whether combination with other cancer therapies causes enhanced toxicity. We used an animal model to investigate wh...

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Опубликовано в: :Radiother Oncol
Главные авторы: Sridharan, Vijayalakshmi, Thomas, Chanice J., Cao, Maohua, Melnyk, Stepan B., Pavliv, Oleksandra, Joseph, Jacob, Singh, Sharda P., Sharma, Sunil, Moros, Eduardo G., Boerma, Marjan
Формат: Artigo
Язык:Inglês
Опубликовано: 2016
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4909572/
https://ncbi.nlm.nih.gov/pubmed/27072940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.radonc.2016.03.027
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