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Inactivation of HDAC1 or HDAC2 induces gamma globin expression without altering cell cycle or proliferation
Other than hydroxyurea, no pharmacologic agents are clinically available for fetal hemoglobin (HbF) induction in sickle cell disease. An optimal candidate would induce HbF without causing cell cycle inhibition and would act independently of hydroxyurea in order to yield additional HbF induction when...
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| Publicado no: | Am J Hematol |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4909492/ https://ncbi.nlm.nih.gov/pubmed/25808664 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ajh.24019 |
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