Lovastatin lactone may improve irritable bowel syndrome with constipation (IBS-C) by inhibiting enzymes in the archaeal methanogenesis pathway

Methane produced by the methanoarchaeon Methanobrevibacter smithii ( M. smithii) has been linked to constipation, irritable bowel syndrome with constipation (IBS-C), and obesity. Lovastatin, which demonstrates a cholesterol-lowering effect by the inhibition of HMG-CoA reductase, may also have an ant...

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Enregistré dans:
Détails bibliographiques
Publié dans:F1000Res
Auteurs principaux: Muskal, Steven M., Sliman, Joe, Kokai-Kun, John, Pimentel, Mark, Wacher, Vince, Gottlieb, Klaus
Format: Artigo
Langue:Inglês
Publié: F1000Research 2016
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4909102/
https://ncbi.nlm.nih.gov/pubmed/27347377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.12688/f1000research.8406.3
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