Limiting collagen turnover via collagenase‐resistance attenuates right ventricular dysfunction and fibrosis in pulmonary arterial hypertension

Pulmonary arterial hypertension (PAH) is a severe form of pulmonary hypertension in which right ventricular (RV) afterload is increased and death typically occurs due to decompensated RV hypertrophy and failure. Collagen accumulation has been implicated in pulmonary artery remodeling, but how it aff...

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Bibliographic Details
Published in:Physiol Rep
Main Authors: Golob, Mark J., Wang, Zhijie, Prostrollo, Anthony J., Hacker, Timothy A., Chesler, Naomi C.
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2016
Subjects:
Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4908492/
https://ncbi.nlm.nih.gov/pubmed/27252252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14814/phy2.12815
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