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Epigenetic activation of Sox2 gene in the developing vertebrate neural plate

One of the earliest manifestations of neural induction is onset of expression of the neural marker Sox2, mediated by the activation of the enhancers N1 and N2. By using loss and gain of function, we find that Sox2 expression requires the activity of JmjD2A and the Msk1 kinase, which can respectively...

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Detalhes bibliográficos
Publicado no:Mol Biol Cell
Main Authors: Bouzas, Santiago O., Marini, Melisa S., Torres Zelada, Eliana, Buzzi, Ailín L., Morales Vicente, David A., Strobl-Mazzulla, Pablo H.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Cell Biology 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4907725/
https://ncbi.nlm.nih.gov/pubmed/27099369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E16-01-0042
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