Phosphodiesterase Type 5 Inhibitors and Risk of Malignant Melanoma: Matched Cohort Study Using Primary Care Data from the UK Clinical Practice Research Datalink

BACKGROUND: Laboratory evidence suggests that reduced phosphodiesterase type 5 (PDE5) expression increases the invasiveness of melanoma cells; hence, pharmacological inhibition of PDE5 could affect melanoma risk. Two major epidemiological studies have investigated this and come to differing conclusi...

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Detalhes bibliográficos
Publicado no:PLoS Med
Main Authors: Matthews, Anthony, Langan, Sinéad M., Douglas, Ian J., Smeeth, Liam, Bhaskaran, Krishnan
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4907438/
https://ncbi.nlm.nih.gov/pubmed/27299522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pmed.1002037
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