Engineering an allosteric transcription factor to respond to new ligands

Genetic regulatory proteins inducible by small molecules are useful synthetic biology tools as sensors and switches. Bacterial allosteric transcription factors (aTFs) are a major class of regulatory proteins, but few aTFs have been redesigned to respond to new effectors beyond natural aTF-inducer pa...

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Detalhes bibliográficos
Publicado no:Nat Methods
Main Authors: Taylor, Noah D, Garruss, Alexander S, Moretti, Rocco, Chan, Sum, Arbing, Mark A, Cascio, Duilio, Rogers, Jameson K, Isaacs, Farren J, Kosuri, Sriram, Baker, David, Fields, Stanley, Church, George M, Raman, Srivatsan
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4907361/
https://ncbi.nlm.nih.gov/pubmed/26689263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmeth.3696
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