Multiple Natural Substitutions in Avian Influenza A Virus PB2 Facilitate Efficient Replication in Human Cells

A strong restriction of the avian influenza A virus polymerase in mammalian cells generally limits viral host-range switching. Although substitutions like E627K in the PB2 polymerase subunit can facilitate polymerase activity to allow replication in mammals, many human H5N1 and H7N9 viruses lack thi...

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Bibliographic Details
Published in:J Virol
Main Authors: Mänz, Benjamin, de Graaf, Miranda, Mögling, Ramona, Richard, Mathilde, Bestebroer, Theo M., Rimmelzwaan, Guus F., Fouchier, Ron A. M.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2016
Subjects:
Virus-Cell Interactions
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4907234/
https://ncbi.nlm.nih.gov/pubmed/27076644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00130-16
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