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Outlier analysis of functional genomic profiles enriches for oncology targets and enables precision medicine

BACKGROUND: Genome-scale functional genomic screens across large cell line panels provide a rich resource for discovering tumor vulnerabilities that can lead to the next generation of targeted therapies. Their data analysis typically has focused on identifying genes whose knockdown enhances response...

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Detalhes bibliográficos
Publicado no:BMC Genomics
Main Authors: Zhu, Zhou, Ihle, Nathan T., Rejto, Paul A., Zarrinkar, Patrick P.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4907009/
https://ncbi.nlm.nih.gov/pubmed/27296290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12864-016-2807-y
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