Eosinophils enhance WNT-5a and TGF-β(1) genes expression in airway smooth muscle cells and promote their proliferation by increased extracellular matrix proteins production in asthma

BACKGROUND: Recent studies have suggested that eosinophils may have a direct effect on airway smooth muscle cells (ASMC), causing their proliferation in patients with asthma, but the precise mechanism of the interaction between these cells remains unknown. We propose that changes in Wnt signaling ac...

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Vydáno v:BMC Pulm Med
Hlavní autoři: Januskevicius, Andrius, Vaitkiene, Simona, Gosens, Reinoud, Janulaityte, Ieva, Hoppenot, Deimante, Sakalauskas, Raimundas, Malakauskas, Kestutis
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2016
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4906992/
https://ncbi.nlm.nih.gov/pubmed/27297409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12890-016-0254-9
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