The Tryptophan Hydroxylase Inhibitor LX1031 Shows Clinical Benefit in Patients With Nonconstipating Irritable Bowel Syndrome

BACKGROUND & AIMS: Serotonin (5-hydroxytryptamine [5-HT]) has an important role in gastrointestinal function. LX1031 is an oral, locally acting, small molecule inhibitor of tryptophan hydroxylase (TPH). Local inhibition of TPH in the gastrointestinal tract might reduce mucosal production of sero...

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書誌詳細
出版年:Gastroenterology
主要な著者: Brown, Philip M., Drossman, Douglas A., Wood, Alastair J. J., Cline, Gary A., Frazier, Kenny S., Jackson, Jessica I., Bronner, Johanna, Freiman, Joel, Zambrowicz, Brian, Sands, Arthur, Gershon, Michael D.
フォーマット: Artigo
言語:Inglês
出版事項: 2011
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4905727/
https://ncbi.nlm.nih.gov/pubmed/21684281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2011.05.005
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