The Tryptophan Hydroxylase Inhibitor LX1031 Shows Clinical Benefit in Patients With Nonconstipating Irritable Bowel Syndrome

BACKGROUND & AIMS: Serotonin (5-hydroxytryptamine [5-HT]) has an important role in gastrointestinal function. LX1031 is an oral, locally acting, small molecule inhibitor of tryptophan hydroxylase (TPH). Local inhibition of TPH in the gastrointestinal tract might reduce mucosal production of sero...

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Vydáno v:Gastroenterology
Hlavní autoři: Brown, Philip M., Drossman, Douglas A., Wood, Alastair J. J., Cline, Gary A., Frazier, Kenny S., Jackson, Jessica I., Bronner, Johanna, Freiman, Joel, Zambrowicz, Brian, Sands, Arthur, Gershon, Michael D.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4905727/
https://ncbi.nlm.nih.gov/pubmed/21684281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2011.05.005
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