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Breaking a paradigm: IL-6/STAT3 signaling suppresses metastatic prostate cancer upon ARF expression

Interleukin 6 (IL-6)/signal transducer and activator of transcription 3 (STAT3) signaling is considered to have important oncogenic functions in prostate cancer (PCa). However, a recent study highlighted the central role of IL-6/STAT3 signaling in regulation of the ARF–MDM2–p53 senescence axis. This...

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Détails bibliographiques
Publié dans:Mol Cell Oncol
Auteurs principaux: Culig, Zoran, Pencik, Jan, Merkel, Olaf, Kenner, Lukas
Format: Artigo
Langue:Inglês
Publié: Taylor & Francis 2016
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4905394/
https://ncbi.nlm.nih.gov/pubmed/27308625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2015.1090048
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