TGF-β receptor 1 inhibition prevents stenosis of tissue-engineered vascular grafts by reducing host mononuclear phagocyte activation

Stenosis is a critical problem in the long-term efficacy of tissue-engineered vascular grafts (TEVGs). We previously showed that host monocyte infiltration and activation within the graft drives stenosis and that TGF-β receptor 1 (TGF-βR1) inhibition can prevent it, but the latter effect was attribu...

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Udgivet i:FASEB J
Main Authors: Lee, Yong-Ung, de Dios Ruiz-Rosado, Juan, Mahler, Nathan, Best, Cameron A., Tara, Shuhei, Yi, Tai, Shoji, Toshihiro, Sugiura, Tadahisa, Lee, Avione Y., Robledo-Avila, Frank, Hibino, Narutoshi, Pober, Jordan S., Shinoka, Toshiharu, Partida-Sanchez, Santiago, Breuer, Christopher K.
Format: Artigo
Sprog:Inglês
Udgivet: Federation of American Societies for Experimental Biology 2016
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4904287/
https://ncbi.nlm.nih.gov/pubmed/27059717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201500179R
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