Mechanistic insights of O-GlcNAcylation that promote progression of cholangiocarcinoma cells via nuclear translocation of NF-κB

O-GlcNAcylation, an O-linked protein glycosylation with a single molecule of N-acetylglucosamine (GlcNAc), is reversibly controlled by O-GlcNAc transferase (OGT) and N-acetyl D-glucosaminidase (OGA). Aberrant O-GlcNAcylation contributes an important role in initiation and progression of many human c...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Phoomak, Chatchai, Vaeteewoottacharn, Kulthida, Sawanyawisuth, Kanlayanee, Seubwai, Wunchana, Wongkham, Chaisiri, Silsirivanit, Atit, Wongkham, Sopit
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4904198/
https://ncbi.nlm.nih.gov/pubmed/27290989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep27853
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