Hyperlipidemia and hepatitis in liver-specific CREB3L3 knockout mice generated using a one-step CRISPR/Cas9 system

cAMP responsive element binding protein 3-like 3 (CREB3L3), a transcription factor expressed in the liver and small intestine, governs fasting-response energy homeostasis. Tissue-specific CREB3L3 knockout mice have not been generated till date. To our knowledge, this is the first study using the one...

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Udgivet i:Sci Rep
Main Authors: Nakagawa, Yoshimi, Oikawa, Fusaka, Mizuno, Seiya, Ohno, Hiroshi, Yagishita, Yuka, Satoh, Aoi, Osaki, Yoshinori, Takei, Kenta, Kikuchi, Takuya, Han, Song-iee, Matsuzaka, Takashi, Iwasaki, Hitoshi, Kobayashi, Kazuto, Yatoh, Shigeru, Yahagi, Naoya, Isaka, Masaaki, Suzuki, Hiroaki, Sone, Hirohito, Takahashi, Satoru, Yamada, Nobuhiro, Shimano, Hitoshi
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4904192/
https://ncbi.nlm.nih.gov/pubmed/27291420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep27857
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