Long-Term Chronic Intermittent Hypobaric Hypoxia in Rats Causes an Imbalance in the Asymmetric Dimethylarginine/Nitric Oxide Pathway and ROS Activity: A Possible Synergistic Mechanism for Altitude Pulmonary Hypertension?

Chronic intermittent hypoxia (CIH) and chronic hypoxia (CH) are associated with high-altitude pulmonary hypertension (HAPH). Asymmetric dimethylarginine (ADMA), a NO synthase (NOS) inhibitor, may contribute to HAPH. This study assessed changes in the ADMA/NO pathway and the underlying mechanisms in...

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Bibliographische Detailangaben
Veröffentlicht in:Pulm Med
Hauptverfasser: Lüneburg, Nicole, Siques, Patricia, Brito, Julio, Arriaza, Karem, Pena, Eduardo, Klose, Hans, Leon-Velarde, Fabiola, Böger, Rainer H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Hindawi Publishing Corporation 2016
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4904121/
https://ncbi.nlm.nih.gov/pubmed/27313889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2016/6578578
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