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Separating Putative Pathogens from Background Contamination with Principal Orthogonal Decomposition: Evidence for Leptospira in the Ugandan Neonatal Septisome

Neonatal sepsis (NS) is responsible for over 1 million yearly deaths worldwide. In the developing world, NS is often treated without an identified microbial pathogen. Amplicon sequencing of the bacterial 16S rRNA gene can be used to identify organisms that are difficult to detect by routine microbio...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Front Med (Lausanne)
Hauptverfasser: Schiff, Steven J., Kiwanuka, Julius, Riggio, Gina, Nguyen, Lan, Mu, Kevin, Sproul, Emily, Bazira, Joel, Mwanga-Amumpaire, Juliet, Tumusiime, Dickson, Nyesigire, Eunice, Lwanga, Nkangi, Bogale, Kaleb T., Kapur, Vivek, Broach, James R., Morton, Sarah U., Warf, Benjamin C., Poss, Mary
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2016
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4904006/
https://ncbi.nlm.nih.gov/pubmed/27379237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmed.2016.00022
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