Assessment of repeatability and treatment response in early phase clinical trials using DCE-MRI: comparison of parametric analysis using MR- and CT-derived arterial input functions

OBJECTIVES: Pharmacokinetic (PK) modelling of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) data requires a reliable measure of the arterial input function (AIF) to robustly characterise tumour vascular properties. This study compared repeatability and treatment-response effects of...

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Detalhes bibliográficos
Publicado no:Eur Radiol
Main Authors: Rata, Mihaela, Collins, David J., Darcy, James, Messiou, Christina, Tunariu, Nina, Desouza, Nandita, Young, Helen, Leach, Martin O., Orton, Matthew R.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2015
Assuntos:
Magnetic Resonance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4902841/
https://ncbi.nlm.nih.gov/pubmed/26385804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00330-015-4012-9
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