Sequence-Specific Protein Aggregation Generates Defined Protein Knockdowns in Plants

Protein aggregation is determined by short (5–15 amino acids) aggregation-prone regions (APRs) of the polypeptide sequence that self-associate in a specific manner to form β-structured inclusions. Here, we demonstrate that the sequence specificity of APRs can be exploited to selectively knock down p...

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Vydáno v:Plant Physiol
Hlavní autoři: Betti, Camilla, Vanhoutte, Isabelle, Coutuer, Silvie, De Rycke, Riet, Mishev, Kiril, Vuylsteke, Marnik, Aesaert, Stijn, Rombaut, Debbie, Gallardo, Rodrigo, De Smet, Frederik, Xu, Jie, Van Lijsebettens, Mieke, Van Breusegem, Frank, Inzé, Dirk, Rousseau, Frederic, Schymkowitz, Joost, Russinova, Eugenia
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Plant Biologists 2016
Témata:
Breakthrough Technologies
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4902617/
https://ncbi.nlm.nih.gov/pubmed/27208282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1104/pp.16.00335
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